CORNEAL CROSS-LINKING (CR3)
SLOW AND STOP THE PROGRESSION OF KERATOCONUS
What is corneal cross-linking (CR3)?
Corneal collagen cross-linking with riboflavin is a new treatment that increases the stiffness and rigidity of the cornea and stabilises keratoconus. Patients who previously had progressive keratoconus have now been treated with CCR (3). They have been followed for over five years with 95% showing no progression of their condition.
Dentists have used collagen cross-linking for many years. Prof. Theo Seiler and Prof. Eberhard Spoerl at the University of Dresden first developed cross-linking as a treatment for the cornea in 1993. The first patients were treated in 1998. Today, eye surgeons perform corneal cross-linking in more than 500 centres around the world. In many centres, it is the standard treatment for keratoconus, which reduces the need for a corneal transplant.
Who is suitable for corneal cross-linking (CR3)?
Cross-Linking is a relatively new treatment and its place in the treatment of keratoconus is still being defined. This will become more apparent as more people are treated around the world, and the results of these treatments are published. To date, the published literature suggests that cross-linking is most suitable for patients with progressive keratoconus. That means patients whose glasses or contact lens prescription is changing quite frequently, or whose vision is becoming worse despite using contact lenses, or whose corneal topography maps show a clear progression of keratoconus.
How do we treat keratoconus?
James Ball explains the different treatment options for treating keratoconus, including corneal cross-linking, intrastromal corneal rings and how he’d like to make corneal transplants for keratoconus no longer needed.
How does corneal cross-linking (CR3) work?
The strength and rigidity of the cornea are partly determined by how strongly the fibres are linked together.Cross-linking uses riboflavin and ultraviolet light to chemically bond the front layers of collagen in the cornea together. This makes the cornea 300% stiffer and stops the progression of keratoconus.
Riboflavin (vitamin B2) is a naturally occurring compound which strongly absorbs UV light. By applying riboflavin to the cornea at the same time as exposing it to a UV light source, the riboflavin enhances the cross-linking effect of the UV light.
Hundreds of ophthalmologists perform cross-linking on tens of thousands of keratoconic patients internationally since 1998.
The cross-linking treatment is carried out with topical anaesthesia (eye drops), which numb the surface of the eye. The patient feels no discomfort during the procedure.
The surface epithelial cell layer is removed from the central part of the cornea, and the riboflavin drops applied.
Once the riboflavin has penetrated into the cornea, the UV light is focussed onto the central area of the cornea for 10 minutes.
Finally, a bandage soft contact lens is applied. The contact lens is worn for up to 2 weeks until the surface epithelial cell layer has re-grown. During the first few days, the eye will be sore and watery.
We advise resting with both eyes shut for as much of the time as possible during the first 48 hrs after the operation. This will significantly improve your comfort in the initial period.
Eye drops will be given that are preventive against infection and inflammation. The use of the eye drops will be discussed with you before you leave the clinic.
You can return to work after one week, resume sports activities after approximately two weeks, and swimming and sauna after approximately three weeks.
You may drive a vehicle again only with the doctor’s permission, usually after the first week.
After the corneal cross-linking operation
In the first period (1-3 months) after cross-linking, you are much more sensitive to light (glare), and the vision is worse for a short time. Only once the cornea has become stable should you consider glasses or contact lenses for definitive correction of any residual spectacle error. Some people choose to seek temporary glasses or contact lenses during the recovery period. In general, a hard contact lens can be worn again after 1- 2 months.
Advantages and disadvantages of corneal cross-linking (CR3)
Benefits of Cross-Linking
Cross-linking is effective in stabilising the progression of keratoconus in the majority of patients. Studies have shown that for about 95% of Keratoconus patients the cross-linking procedure prevents further vision loss.
In a minority of patients, the treatment gives an additional small measure of benefit in reducing the corneal steepness and irregularity. This, in turn, means some reduction in the short-sightedness and astigmatism associated with keratoconus.
Risks of Cross-Linking
Potential complications of cross-linking are rare. They include corneal haze, corneal infection, corneal inflammation, corneal scarring, and the need for repeat surgery.
Options and alternatives to corneal cross-linking (CR3)
Ophthalmic surgeons can combine cross-linking with intracorneal or intrastromal rings to flatten the keratoconus cone even more. The rings stabilise keratoconus which prevents it from getting worse. The intracorneal or intrastromal rings also reverse the keratoconus steepening that has occurred before the treatment.
Further information about corneal cross-linking (CR3)
MORE USEFUL INFORMATION
Read more about keratoconus surgery
Custom Vision Clinic’s YouTube Channel features James Ball answering hundreds of eye-related questions on video – ranging from laser refractive surgery, lens exchange and keratoconus treatment. Click here for more information
Laser eye surgery reviews of Custom Vision Clinic on Trustpilot. Click here for more information
One of the UK’s leading sight loss charities and the largest community of blind and partially sighted people publishes information about keratoconus. Read more.
The UK Keratoconus Self-Help and Support Association (includes a discussion group and links to resources). Read more.
Cornea transplants are usually performed to correct problems with your eyesight caused by certain medical conditions. Read more…
About the author
Mr James Ball | Consultant Ophthalmic Surgeon
MA (Cantab) MB BChir FRCOphth CertLRS
I am a Consultant Ophthalmic Surgeon at Custom Vision Clinic, The Yorkshire Eye Hospital, St James’s University Hospital, and Nuffield Hospital. My major interest is in refractive surgery and finding the best treatment suitable for each patient.